Directrices de reproducibilidad, criterios de corrección Benjamini-Hochberg FDR (q < 0.05), desescalamiento allométrico de volumen (TIV) y aprobación ética IRB #24-819.
OPEN SCIENCE REPOSITORY • IRB PROTOCOL #24-819
Methodology & Ethical Neurobiology
Our framework enforces strict false-discovery rate control, allometric volume scaling, and data harmonization to prevent spurious claims of dimorphism.
01
STATISTICAL CORRECTION CRITERIA
Benjamini-Hochberg False Discovery Rate (FDR) Control
Historically, neuroimaging literature suffered from high false-positive rates due to uncorrected voxel-wise comparisons across tens of thousands of coordinates. In DualBrain syntheses, we mandate an empirical FDR cutoff of q < 0.05 across all diffusion tractography and morphometric analyses.
P(k) ≤ (k / m) × Q • where m = total voxel tests, Q = 0.05
02
ALLOMETRIC SCALING
Total Intracranial Volume (TIV) Decoupling
Adult human male craniums are on average 10% larger than female craniums due to overall body stature. When studies fail to account for non-linear power-law scaling, differences in subcortical volumes (such as the amygdala or hippocampus) are misattributed to sex rather than allometric head volume.
Uncorrected Literature
Reports large effect sizes in subcortical volume disparity between sexes.
TIV Allometric Model
Effect sizes collapse below Cohen's d = 0.12, confirming morphological overlap.
03
DATA INTEGRATION
Multi-Site Neuroimaging Harmonization
We employ the ComBat empirical Bayes batch-effect correction algorithm across four premier open-science datasets:
UK Biobank Neuroimaging
n = 40,000+ Scans
Human Connectome Project (HCP S1200)
n = 1,200 Diffusion Sets
Philadelphia Neurodevelopmental Cohort
n = 1,601 Lifespan Traces
Preventing Neurosexism & Essentialist Fallacies
Biological sex operates as one among many interacting physiological variables alongside developmental experiences, socialization, physical activity, and circulating neurochemicals. The DualBrain consortium firmly rejects reductive binary determinism in cognitive capability evaluations.